Cell Alignment

Myocardial infarction (MI) is the main cause of heart failure. The heart does not regenerate effectively and cannot replenish the damaged tissues after injury. Therefore, damaged myocardial tissue eventually becomes scar tissue which can severely hinder the proper function of the heart and can be deadly to the patient. In recent years, human embryonic stem cells (hESCs) have been introduced as a potential treatment option to improve heart function after MI. Our research goal is to create a cardiac patch for the treatment of MI. The specific aims include direct differentiation of cardiomyocytes from hESCs, maturation of cardiomyocytes through biomimetic cues, and creating a cardiac patch using those functional and mature cardiomyocytes.




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