Publications

See Latest Publication List @ Michelle Khine Google Scholar

2024

• Abiri, A., Zhou, Y., Rahmani, A., Khayat, R., Kazemi, K., Liljeberg, P., Improved Sleep Stage Predictions by Deep Learning of Photoplethysmogram and Respiration Patterns. Computers in Biology and Medicine (accepted)

2023

• Hajiaghajani, A., Rwei, P., Afandizadeh Zargari, A.H. et al. Amphibious epidermal area networks for uninterrupted wireless data and power transfer. Nat Commun 14, 7522 (2023). https://doi.org/10.1038/s41467-023-43344-6

• Abiri, A., Chou, EF., Shen, W. et al. Changes in beat-to-beat blood pressure and pulse rate variability following stroke. Sci Rep 13, 19245 (2023). https://doi.org/10.1038/s41598-023-45479-4

2022

• Giró Benet J, Seo M, Khine M, Gumà Padró J, Pardo Martnez A, Kurdahi F. Breast cancer detection by analyzing the volatile organic compound (VOC) signature in human urine. Sci Rep. 2022 Sep 1;12(1):14873.

• Rwei, P., Qian, C., Abiri, A., Zhou, Y., Chou, E.-F., Tang, W. C., Khine, M., Soft Iontronic Capacitive Sensor for Beat-to-Beat Blood Pressure Measurements. Adv. Mater. Interfaces 2022, 9, 2200294.

2021

• Zhou, Y., Werner, E. M., Lee, E., Chu, M., Nguyen, T., Costa, K. D., … & Khine, M. (2021). High-resolution Integrated Piezoresistive Sensors for Microfluidic Monitoring. Lab on a Chip, 21(1), 83-92.

• Nguyen, T., Chu, M., Tu, R., & Khine, M. (2021). The Effect of Encapsulation on Crack-Based Wrinkled Thin Film Soft Strain Sensors. Materials, 14(2), 364.

• Lin, L., Dautta, M., Hajiaghajani, A., Escobar, A. R., Tseng, P., & Khine, M. (2021). Paint‐On Epidermal Electronics for On‐Demand Sensors and Circuits. Advanced Electronic Materials, 7(1), 2000765.

• Li, S., Lin, L., Chang, X., Si, Z., Plaxco, K. W., Khine, M., … & Xia, F. (2021). A wrinkled Structure of Gold Film Greatly Improves the Signaling of Electrochemical Aptamer-based Biosensors. RSC Advances, 11(2), 671-677.

• Zakashansky, J. A., Imamura, A. H., Salgado, D. F., Mercieca, H. C. R., Aguas, R. F. L., Lao, A. M., … & Khine, M. (2021). Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes. Accepted to Analytical Methods.

2020

• Imamura, A., Zakashansky, J., Cho, K., Lin, L., Carrilho, E., & Khine, M. (2020). Stretchable Sensors for Nanomolar Glucose Detection. Advanced Materials Technologies, 5(4), 1900843.

• Le, T., Ellington, F., Lee, T. Y., Vo, K., Khine, M., Krishnan, S., … & Cao, H. (2020). Continuous Non-Invasive Blood Pressure Monitoring: A Methodological Review on Measurement Techniques. IEEE Access.

• Nguyen, T., & Khine, M. (2020). Advances in Materials for Soft Stretchable Conductors and Their Behavior under Mechanical Deformation. Polymers, 12(7), 1454.

• Wong, A. O. T., Wong, N., Geng, L., Chow, M. Z. Y., Lee, E. K., Wu, H., … & Li, R. A. (2020). Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients. Frontiers in physiology, 11, 165.

2019

• Shum, A., Wong, A. O., Chan, C. W., Costa, K. D., Khine, M., Kong, C. W., & Li, R. A. (2019). Directly Visualizing Drug-induced Arrhythmias With Aligned Human Pluripotent Stem Cell-based Ventricular Cardiac Anisotropic Sheet. Journal of pharmacological and toxicological methods, 99, 106595-106595.

• Kim, J., Chou, E. F., Le, J., Wong, S., Chu, M., & Khine, M. (2019). Soft Wearable Pressure Sensors for Beat‐to‐Beat Blood Pressure Monitoring. Advanced healthcare materials, 8(13), 1900109.

• King, C. E., Hoo, C. M., Tang, W. C., & Khine, M. (2019). Introducing Entrepreneurship Into A Biomedical Engineering Capstone Course At The University of California, Irvine. Technology & Innovation, 20(3), 179-195.

• Chu, M., Nguyen, T., Pandey, V., Zhou, Y., Bar-Yoseph, R., Radom-Aizik, S., Jain, R., Cooper, D. and Pham, H., Khine, M.* (2019). Respiration Rate and Volume Measurements using Wearable Strain Sensors, NPJ Digital Medicine, 2(1), 1-9.

• Lin, L., Chu, M., Park, S. J., Zakashansky, J. A., & Khine, M*. (2019). Conformal Stretch Sensors for High Resolution Motion Sensing and Control. Macromolecular Materials and Engineering, 304(4), 1800520.

• Lee, E. K., Tran, D. D., Keung, W., Chan, P. K., Wong, G. K., Chan, C. W., Costa, K., D., Khine, M. & Li, R. A. (2019). Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification. Journal of pharmacological and toxicological methods, 99, 106595.

• Leser, M., Chapman, J. R., Khine, M., Pegan, J., Law, M., Makkaoui, M. E., … & Brenowitz, M. (2019). Chemical Generation of Hydroxyl Radical for Oxidative ‘Footprinting’. Protein and peptide letters, 26(1), 61-69.

2018

• Piltti KM, Cummings BJ, Carta K, Manughian-Peter A, Worne CL, Singh K, Ong D, Maksymyuk Y, Khine M, Anderson AJ Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells – Tools for analyzing dynamics of cell cycle, migration, and lineage selection, Methods. 2018 Jan 15;133:81-90. doi: 10.1016/j.ymeth.2017.10.003.

• Heikenfeld, J., Jajack, A., Rogers, J., Gutruf, P., Tian, L., Pan, T., Li, R., Khine, M., Kim, J., Wang, J., Kim, J. (2018). Wearable sensors: modalities, challenges, and prospects. Lab on a Chip, 18, 217-248. doi: 10.1039/c7lc00914c

• Park, S. J., Kim, J., Chu, M., & Khine, M. (2018). FFlexible Piezoresistive Pressure Sensor Using Wrinkled Carbon Nanotube Thin Films for Human Physiological Signals. Advanced Materials Technologies, 3(1), 1700158.

2017

• Hauke, A., Kumar, L.S., Kim, M.Y., Pegan, J., Khine, M., Li, H.,Plaxco, K.W., Heikenfeld, J. Superwetting and aptamer functionalized shrink-induced high surface area electrochemical sensors. Biosensors and Bioelectronics, 94(March), 438-442. doi: 10.1016/j.bios.2017.03.024.

• Chu, M., Nguyen, T., T. Lee, E.B., Morival, J.L., Khine,M.* Plasma Free Reversible and Permanent Microfluidic Bonding, Lab Chip (2017)17, 267-273.

• Shum, A. M. Y , Che, H., O.T. Wong, Wu, H., Chan, C., Khine, M., Costa K., Li, R., A micro-patterned human pluripotent stem cell-based cardiac ventricular sheet for visualizing drug-induced arrhythmogenicity, Advanced Materials (2017) doi: 10.1002/adma.201602448.

2016

• Park, S.J., Kim, J., Chu, M., Khine, M Highly Flexible Wrinkled Carbon Nanotube Thin Film Strain Sensors to Monitor Human Movement, Adv. Mater. Tech. (2016)

• Pegan, J.D., Zhang, J., Chu, M., Nguyen, T., Park, S.J., Paul, A., Kim, J., Bachman, M., Khine, M.* Skin-Mountable Stretch Sensor for Wearable Health Monitoring, Nanoscale, (2016) 8, 17295-17303.

• Lin, S., Hedde, P. N., Venugopalan, V., Gratton, E., and Khine, M. Multi-scale silica structures for improved HIV-1 Capsid (p24) antigen detection, Analyst (2016). doi:10.1039/C6AN00519E

• Luu, W.T., Chen, A., Khine, M., and Liu, W. Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles, Biomater. Sci. (2016). 4, 948-952 doi:10.1039/C6BM00224B

• Nokes, J.M., Sharma, H., Tu, R., Kim, M.Y., Chu, M., Siddiqui, A., and Khine, M. Nanotextured Shrink Wrap Superhydrophobic Surfaces by Argon Plasma Etching, Materials (2016), 9(3). doi:10.3390/ma9030196

• Sharac, N., Sharma, H., Veysi, M., Sanderson, R.N., Khine, M., Capolino, F., and Ragan, R. Tunable optical response of bowtie nanoantenna arrays on thermoplastic substrates, (2016). Nanotechnology 27

• Kim, J., Park, S.-J., Nguyen, T., Chu, M., Pegan, J. D., and Khine, M., Highly stretchable wrinkled gold thin film wires, Appl. Phys. Lett., (2016). DOI: http://dx.doi.org/10.1063/1.4941439

• Nokes, J. M., Liedert, R., Kim, M. Y., Siddiqui, A., Chu, M., Lee, E.K., and Khine, M., Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics, Adv. Healthcare Mater., (2016). DOI: 10.1002/adhm.201500697

2015

• Lee, E.K., Kurokawan Y.K., Tu, R., George, S. C., and Khine, M. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs, Scientific Reports, (2015). DOI: 10.1038/srep11817

• M. Leser, J. Pegan, M. El Makkaoui, J. C. Schlatterer, M. Khine, M. Law and M. Brenowitz, Protein footprinting by pyrite shrink-wrap laminate, Lab Chip, (2015). DOI: 10.1039/C4LC01288G

2014

• Lin, S., Lee, E., Nguyen, N., Khine, M., Thermally-induced miniaturization for micro- and nanofabrication: progress and updates, Lab Chip, (2014).

• McLane, J., Wu, C., Khine, M., Enhanced Detection of Protein in Urine by Evaporation on a Superhydrophobic Plastic, Advanced Materials Interfaces, (2014).

• Sharma H., Digman M., Felsinger N., Gratton E., and Khine M., Enhanced emission of fluorophores on shrink-induced wrinkled composite structures, Opt. Mater. Express 4, 753-763 (2014)

2013

• Chen, A., Lee, E., Tu, R., Santiago, K., Grosberg, A., Fowlkes, C., Khine, M. (2013) Integrated Platform for Functional Monitoring of Biomimetic Heart Sheets Derived From Human Pluripotent Stem Cells. Biomaterials.

• Wang, J., Chen, A., Lieu, D.K., Karakikes, I., Chen, G., Keung, W., Chan, C.W., Hajjar, R.J., Costa, K.D., Khine, M., Li, R.A. (2013) Effect of Engineered Anisotropy on the Susceptibility of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes to Arrhythmias. Biomaterials. 34(35): 8878-8886.

• Pegan, J., Ho, A., Bachman, M., and Khine, M., Flexible Shrink-Induced High Surface Area Electrodes for Electrochemiluminescent Sensing. Lab Chip, 2013, DOI: 10.1039/C3LC50588J

• Lin, S., Sharma, H. and Khine, M. (2013), Shrink-Induced Silica Structures for Far-field Fluorescence Enhancements. Advanced Optical Materials. doi: 10.1002/adom.201300180

• Nawarathna, D., Norouzi, N., Sharma, H., Sharac, N., Grant, T., Chen, A., McLane,J., Strayer, S., Ragan, R., Khine, M.*, “Shrink-Induced Microfluidic Sorting using Integrated Nanoscale Magnetic Traps,” Applied Physics Letter, 102, 063504 (2013).

• Ferri, C. G. L, Inman, R.H., Rich, B., Gopinathan, A., Khine, M., Ghosh, S.*, “Plasmon-induced enhancement of intra-ensemble FRET in quantum dots on wrinkled thin films,” Optical Express Materials, 3, 3, 383-389 (2013)

• Jayadev, S., Pegan, J., Dyer D., McLane, J., Lim, J., Khine, M. “Adaptive Wettability-enhanced Surfaces Ordered on Molded Etched Substrates Using Shrink Film,” Smart Mater. Struct. 22 (2013) 014014

2012

• Hinde, E., Cardarelli, F., Chen, A., Khine, M., Gratton, E. (2012). Tracking the Mechanical Dynamics of Human Embryonic Stem Cell Chromatin. Epigenetics & Chromatin. 5(20): 1-11.

• Freschauf L.R., McLane J., Sharma H., Khine M. (2012) “Shrink-Induced Superhydrophobic and Antibacterial Surfaces in Consumer Plastics,” PLoS ONE 7(8): e40987. doi:10.1371/journal.pone.0040987

2011

• Chen, A., Lieu, D.K., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R.J., Gopinathan, A., Botvinick, E., Fowlkes, C.C., Li, R.A., Khine, M., “Shrink-Film Configurable Multi-scale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives,” Advanced Materials, 2011, 23(48):5785-5791.

• Lew, V., Nguyen, D., Khine, M., “Shrink-Induced Single-Cell Plastic Microwell Array,” Journal of Laboratory Automation, 2011, doi:10.1016/j.jala.2011.06.003.

• Dyer, D., Shreim, S., Jayadev, S., Lew, V., Botvinick, E., Khine, M., “Sequential shrink photolithography for plastic microlens arrays,” Applied Physics Letters, 99, 3, 2011, doi:10.1063/1.3609322.

• Nguyen, D., Mclane J., Lew, V., Pegan, J., Khine, M., “Shrink-film microfluidic education modules: Complete devices within minutes,”Biomicrofluidics, 5, 2011, doi:10.1063/1.3576930.

• J. Luna, J. Ciriza, M. Ojeda-Garcia, M. Kong, A. Herren, D. Lieu, R. Li, C. Fowlkes, M. Khine, K. McCloskey, “Multiscale Biomimetic Topography for the Alignment of Neonatal and Embryonic Stem Cell-Derived Heart Cells,” Tissue Engineering: Part C, 17, 5, 2011, 579-588.

• Sharma, H., Nguyen, D., Chen, A., Lew, V., Khine, M., “Unconventional Low-Cost Fabrication and Patterning Techniques for Point of Care Diagnostics,” Annals of Biomedical Engineering, 39, 4, 2011, 1313-1327.

• Chen, A., Sharma, H., Nguyen, D., Zarandi, SM., Khine, M. “Think Big Then Shrink: Low Cost, Ultra-Rapid Tunable Nanowrinkles from Shape Memory Polymers.” Bionanotechnology: Global Prospects II. CRC Press. 2011. Print.

2010

• Fu, C.C., Ossato, G. Long, M., Digman, M., Gopinathan, A., Lee, L., Gratton, E., Khine, M., “Bimetallic nanopetals for thousand-fold fluorescence enhancements,” Applied Physics Letters, 97, 20, 2010, 203101.

• Taylor, D., Dyer, D., Lew, V., Khine, M., “Shrink film patterning by craft cutter: complete plastic chips with high resolution/high-aspect ratio channel,” Lab on a Chip, 2010, 10, 2472-2475.

• Long, M., Khine, M., Kim, A.D., “Scattering of light by molecules over a rough surface,” Journal of Optical Society of America A, 2010, 27, 5, 1002-1011.

• Nguyen, D., Taylor, D., Qian, K., Norouzi, N., Rasmussen, J., Botzet, S., Lehmann, M., Halverson, K., Khine, M., “Better shrinkage than Shrinky-Dinks,” Lab on a Chip, 2010, 10, 1623-1626.

2009

• Nguyen, D., Sa, S., Pegan, J.D., Rich, B., Xiang, G., McCloskey, K.E, Manilay, J.O., Khine, M., “Tunable shrink-induced honeycomb microwell arrays for uniform embryoid bodies,” Lab on a Chip, 2009, 9, 3338-3344.

• Fu, C.C., Grimes, A., Long, M., Ferri, C.G.L., Rich, B.D., Ghosh, S., Ghosh, S., Lee, L.P., Gopinathan, A., Khine, M., “Tunable Nanowrinkles on Shape Memory Polymer Sheets,” Advanced Materials, 2009, 21.

• Long, M., Sprague, M.A., Grimes, A.A., Rich, B.D., and Khine, M., “A simple three-dimensional vortex micromixer,” Applied Physics Letters, 2009, 94, 133501.

• Grimes, A.A., Rich, B.D., Long, M., Nguyen, D., and Khine, M. Shrinky-Dink Microfluidics, Lab on a Chip Technology (Vol. 1): Fabrication and Microfluidics (eds K.E. Herold and A. Rasooly), Caister Academic Press. (2009)

2008

• Chen, C.S., Pegan, J., Luna, J., Xia, B., McCloskey K., Chin, W.C., Khine, M., “Shrinky-Dink Hanging Drops: A Simple Way to Form and Culture Embryoid Bodies” (2008)

• Chen, C.S., Breslauer, D.N., Luna, J.I., Grimes, A., Chin, W.C., Lee, L.P., Khine, M.,” “Shrinky-Dink Microfluidics: 3-D Polystyrene Chips,” Lab on a Chip, 2008, 8, 622-624.

• Grimes, A., Breslauer, D.N., Pegan, J., Long, M., Lee, L.P., Khine, M., “Shrinky Dink Microfluidics: Rapid Generation of Deep and Rounded Channels,” The Royal Society of Chemistry Journal, Lab on a Chip, 2008, 8, 170-172. Highlighted in Chemical and Engineering News (November 27th, 2007), on the Front page of American Chemical Society Homepage, (acs.org), front page of Lab Chip Homepage (http://www.rsc.org/Publishing/Journals/lc/), Chemical Technology (December 5th 2007) and Wired Science (December 4th 2007).

• Ionescu-Zanetti, C., Blatz, A., Khine, M., “Electrophoresis-assisted single-cell electroporation for efficient intracellular delivery”Biomedical Microdevices, 2008, 10:113-116.

2007

• Khine, M., Ionescu-Zanetti, Wang, L.P., Blatz, A., Lee, L.P., “Single-Cell electroporation arrays with real-time monitoring and feedback control,” Lab on a Chip, 2007, 7, 457-462. Highlighted in and cover of Genomics Technology Magazine, May 2007. Highlighted in Biology in Focus, June 26, 2007 for its impact on microarrays.

2005

• Khine, M. & Lau, A., Ionescu-Zanetti, C., Seo, J., Lee, L.P., “A Single Cell Electroporation Chip,” Lab on a Chip, 2005, 5, 38-43. Selected as a “hot article” in Lab on a Chip and for the Special Issue “Cells in miniaturized systems” January 2005, this article is also highlighted in Chemical Science for its impact on cellular bioassays. Highlighted in the Scientist July 2005.

2003

• Khine, M., Thompson, J.K., Bierer, S.M., Altamirano, L.J., Freeman, R.D., Lee, L.P, ” A combined neural-oxygen sensing multi-channel electrode array,” Neural Engineering, IEEE EMBS Conference Proceedings 2003.

1998

• Khine, M. & Klavins, J.V., “Using AFP to Detect Fetal Abnormalities” Journal of Tumor Marker Oncology, 10, 131-134, 1998.